1. Ausgewählte Übersichtsarbeit zu Spermidin

Madeo, Frank et al. “Nutritional Aspects of Spermidine.” Annual review of nutrition vol. 40 (2020): 135-159. doi:10.1146/annurev-nutr-120419-015419

2. Präklinische Grundlagenforschung zum Wirkmechanismus von Spermidin

Hofer, Sebastian J et al. “Mechanisms of spermidine-induced autophagy and geroprotection.” Nature aging vol. 2,12 (2022): 1112-1129. doi:10.1038/s43587-022-00322-9

3. Epidemiologische Studiendaten einer spermidinreichen Ernährung

• Kiechl, Stefan et al. “Higher spermidine intake is linked to lower mortality: a prospective population-based study.” The American journal of clinical nutrition vol. 108,2 (2018): 371-380. doi:10.1093/ajcn/nqy102
• López-González, Andrés et al. “Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome.” European journal of nutrition vol. 65,5 214. 15 Jul. 2026, doi:10.1007/s00394-026-03981-1
• Qi, Guolian et al. “Association between dietary spermidine intake and depressive symptoms among US adults: National Health and Nutrition Examination Survey (NHANES) 2005-2014.” Journal of affective disorders vol. 359 (2024): 125-132. doi:10.1016/j.jad.2024.05.041
• Schroeder, Sabrina et al. “Dietary spermidine improves cognitive function.” Cell reports vol. 35,2 (2021): 108985. doi:10.1016/j.celrep.2021.108985

4. Klinische Interventionsstudien einer Spermidin-Supplementierung

• Alsaleh, Ghada et al. “Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.” Aging cell vol. 25,6 (2026): e70545. doi:10.1111/acel.70545
• Mackert, Sarah et al. “Spermidine alleviates depression via control of the stress response.” bioRxiv : the preprint server for biology 2024.12.04.626625. 7 Dec. 2024, doi:10.1101/2024.12.04.626625. Preprint.

5. Vollblut-Spermidin-Spiegel als Longevity-Biomarker

Pucciarelli, Stefania et al. “Spermidine and spermine are enriched in whole blood of nona/centenarians.” Rejuvenation research vol. 15,6 (2012): 590-5. doi:10.1089/rej.2012.1349

Der natürliche Mechanismus zellulärer Reinigung und Regeneration und seine Bedeutung für das gesunde Altern.

Ausgewählte Übersichtsarbeiten und Forschungsartikel

• Aman, Yahyah et al. “Autophagy in healthy aging and disease.” Nature aging vol. 1,8 (2021): 634-650. doi:10.1038/s43587-021-00098-4
• López-Otín, Carlos et al. “Hallmarks of aging: An expanding universe.” Cell vol. 186,2 (2023): 243-278. doi:10.1016/j.cell.2022.11.001
• Yang, Liang et al. “Stress dynamically modulates neuronal autophagy to gate depression onset.” Nature vol. 641,8062 (2025): 427-437. doi:10.1038/s41586-025-08807-4