Wissenschaftliche Quellen und Evidenzen der genannten Anwendungsfelder von Spermidin in der therapeutischen Praxis

1 Madeo F, Hofer SJ, Pendl T, et al. Nutritional Aspects of Spermidine. Annu Rev Nutr. 2020;40:135-159.

2 Aman Y, Schmauck-Medina T, Hansen M, et al. Autophagy in healthy aging and disease. Nat Aging. 2021;1(8):634-650.

3 Kiechl S, Pechlaner R, Willeit P, et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018;108(2):371-380.

4 Schroeder S, Hofer SJ, Zimmermann A, et al. Dietary spermidine improves cognitive function. Cell Rep. 2021;35(2):108985.

5 Qi G, Wang J, Chen Y, Wei W, Sun C. Association between dietary spermidine intake and depressive symptoms among US adults: National Health and Nutrition Examination Survey (NHANES) 2005-2014. J Affect Disord. 2024;359:125-132.

6 López-González A, Cuadrado-Soto E, et al. Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome. Eur J Nutr. 2026;65(5):214.

7 Alsaleh G, Ali M, Kayvanjoo AH, et al. Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study. Aging Cell. 2026;25(6):e70545. doi:10.1111/acel.70545.

8 Niechcial A, Schwarzfischer M, Wawrzyniak M, et al. Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis. J Crohns Colitis. 2023;17(9):1489-1503.

9 Matsumoto M, Kurihara S, Kibe R, Ashida H, Benno Y. Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production. PLoS One. 2011;6(8):e23652.

10 Matsumoto M. Prevention of Atherosclerosis by the Induction of Microbial Polyamine Production in the Intestinal Lumen. Biol Pharm Bull. 2020;43(2):221-229.